Treating cataplexy professional#
This testing often takes place overnight at a sleep clinic, under the watch of professional medical staff. If symptoms of narcolepsy are visible, provide evidence & ask your doctor to refer you for further testing with a specialist. Source: US National Institute of Health: NHLBI Heredity/Genes create a disposition towards developing narcolepsy, rather than causing the disorder itself. " Toxins may include heavy metals, pesticides and weed killers, and secondhand smoke." Some research suggests that environmental toxins may also trigger narcolepsy.
It is thought that a combination of the following factors cause low levels of hypocretin: What causes low hypocretin levels isn't well understood. This is a chemical in the brain that helps promote wakefulness. Most people who have narcolepsy have low levels of hypocretin. Narcoleptics suffer from the inability to remain awake during the day and to stay asleep through the night. The name is from the ancient Greek narco- ( to put to sleep) & -lepsis ( to have a seizure).
Treating cataplexy how to#
Sleep Study or Polysomnogram, What to Expect & How to Prepare Your question may have already been answered. Please read the following posts before asking questions.Great user posts/responses are going to be posted here from now until the wiki is up and running.The most common adverse reactions were headache, nausea, dizziness, decreased appetite, parasomnia, diarrhea, hyperhidrosis, anxiety, and vomiting.New to Narcolepsy? Please read our Wiki page! Subreddit Links Due to the risks of CNS depression and abuse and misuse, Xywav is available only through a restricted program under a REMS called the Xywav and Xyrem REMS Program. Xywav has a Boxed Warning as a central nervous system (CNS) depressant, and for its potential for abuse and misuse. Sodium oxybate comes with warnings about high sodium content, but is the only previously approved treatment for both cataplexy and EDS in patients with narcolepsy. “This may help patients taking sodium oxybate better align with daily sodium intake recommendations including those by the American Heart Association.” Bogan, MD, FCCP, FAASM, associate clinical professor at the University of South Carolina School of Medicine, said in a statement. “Based on the efficacy demonstrated in the clinical program, the approval of Xywav is important for people living with cataplexy or EDS associated with narcolepsy,” Richard K. The company also announced plans to launch the drug by the end of 2020 following the implementation of a Risk Evaluation and Mitigation Strategy (REMS). When patients start the new treatment following sodium oxybate, Xywav treatment is initiated at the same dose and regimen as sodium oxybate and titrated as needed based on efficacy and tolerability. Multiple dosing options are available for both adult and pediatric patients and prescribers can titrate Xywav into unequal doses over the course of a night. Xywav showed statistically significant differences ( P <0.0001) in weekly number of cataplexy attacks and Epworth Sleepiness Scale scores compared to placebo. The approval is based on a phase 3 double-blind, placebo-controlled, randomized-withdrawal, multicenter that showed the efficacy and safety of the treatment of 201 patients. The oxybate drug, developed by Jazz Pharmaceuticals, is a composition of cations that result in 92% less sodium or approximately 1000-1500 mg per night less sodium than sodium oxybate at the recommended dosage of 6-9 grams.
The US Food and Drug Administration (FDA) has approved Xywav (calcium, magnesium, potassium, and sodium oxybates) oral solution for the treatment of cataplexy and excessive daytime sleepiness (EDS) in patients at least 7 years old with narcolepsy.
0 kommentar(er)
